Добавлено: Ср Мар 01, 2017 6:28 am Заголовок сообщения: Передача клеток от зародыша к матери
Cell Migration from Baby to Mother
Gavin S Dawe, Xiao Wei Tan, and Zhi-Cheng Xiao
Additional article information
Fetal cells migrate into the mother during pregnancy. Fetomaternal transfer probably occurs in all pregnancies and in humans the fetal cells can persist for decades. Microchimeric fetal cells are found in various maternal tissues and organs including blood, bone marrow, skin and liver. In mice, fetal cells have also been found in the brain. The fetal cells also appear to target sites of injury. Fetomaternal microchimerism may have important implications for the immune status of women, influencing autoimmunity and tolerance to transplants. Further understanding of the ability of fetal cells to cross both the placental and blood-brain barriers, to migrate into diverse tissues, and to differentiate into multiple cell types may also advance strategies for intravenous transplantation of stem cells for cytotherapeutic repair. Here we discuss hypotheses for how fetal cells cross the placental and blood-brain barriers and the persistence and distribution of fetal cells in the mother.
Добавлено: Ср Мар 01, 2017 6:29 am Заголовок сообщения:
Moreover fetal cells are reported to persist in the mother for decades. Male cells have been found in maternal blood even decades after pregnancy,7,77 including in one case in which the women was last pregnant with a male child 27 years earlier.7 Fetal cells also may persist for even longer after engrafting maternal bone marrow14 and perhaps other organs. By engrafting into niches such as the bone marrow, fetal cells may also be able to proliferate and reinfiltrate blood or other tissues later. There is strong evidence that fetal cells with the characteristics of mesenchymal cells do engraft the bone marrow. Male DNA was detected in 48% of CD34-enriched apheresis products from nonpregnant female marrow donors.1 Male cells were also detected in all bone marrow samples from women who had previously been pregnant with males, including one woman who was last pregnant with a son 51 years earlier.14... _________________ Сильный гнев мудреца и война храбреца испытает...
А больную кровь да в лесу людском чуять русичу был отцов наказ...